MK-571 sodium salt
Cat. No.：YN321260
CAS No. ：115103-85-0
| 产品名称: | MK-571 sodium salt |
| CAS No.: | 115103-85-0 |
| Chemical Name: | (E)-3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt |
| Synonyms: | L-660711 sodium salt |
| 分子量: | 537.07 |
| 分子式: | C₂₆H₂₆ClN₂NaO₃S₂ |
| SMILES: | O=C(O[Na])CCSC(C1=CC=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=C1)SCCC(N(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-571 sodium salt是一种选择性，口服活性的白三烯D4受体拮抗剂，在豚鼠和人肺膜的Ki分别为0.22 和 2.1 nM。 |
| IC50和靶点: | [{name:"LTD4:0.22±0.15 nM (Ki, In guinea pig lung)"},{name: "LTD4:2.1±1.8 nM (Ki, In human lung)"},{name: "LTD4:10.5 (pA2)"},{name: "LTE4:10.4 (pA2)"}] |
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Jones, T.R., Zamboni, R., Belley, M., et al.Pharmacology of L-660,711 (MK-571): A novel potent and selective leukotriene D4 receptor antagonistCan. J. Physiol. Pharmacol.67(1),17-28(1989)
Lynch, K.R., O'Neill, G.P., Liu, Q., et al.Characterization of the human cysteinyl leukotriene CysLT1 receptorNature399(6738),789-793(1999)
da Cunha, A.A., Silveira, J.S., Antunes, G.L., et al.Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthmaExp. Lung Res.47(8),355-367(2021)
