Pranlukast
Cat. No.：YN321444
| 产品名称: | Pranlukast |
| CAS No.: | 103177-37-3 |
| Chemical Name: | N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide |
| Synonyms: | 普鲁司特; ONO-1078 |
| 分子量: | 481.50 |
| 分子式: | C₂₇H₂₃N₅O₄ |
| SMILES: | O=C(NC1=C2C(C(C=C(C3=NNN=N3)O2)=O)=CC=C1)C4=CC=C(OCCCCC5=CC=CC=C5)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pranlukast 是一种高效的竞争性的选择性leukotriene拮抗剂。Pranlukast 抑制 [3H]LTE4，[3H]LTD4和 [3H]LTC4与肺膜结合，Ki分别为 0.63±0.11，0.99±0.19 和 5640±680 nM。 |
| IC50和靶点: | [{name:"LTE4:0.63 nM (Ki)"},{name: "LTD4:0.99 nM (Ki)"},{name: "LTC4:5640 nM (Ki)"}] |
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Liu, Y.-C., Khawaja, A.M., and Rogers, D.F.Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitroBr. J. Pharmacol.124(3),563-571(1998)
Ichiyama, T., Hasegawa, S., Umeda, M., et al.Pranlukast inhibits NF-KB activation in human monocytes/macrophages and T cellsClin. Exp. Allergy33(6),802-807(2003)
Nakai, H., Konno, M., Kosuge, S., et al.New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationshipsJ. Med. Chem.31(1),84-91(1988)
Zhang, W.-P., Wei, E.-Q., Mei, R.-H., et al.Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in ratsActa Pharmacol. Sin.23(10),871-877(2002)
