5-O-Demethylnobiletin
Cat. No.：YN321741
| 产品名称: | 5-O-Demethylnobiletin |
| CAS No.: | 2174-59-6 |
| Chemical Name: | 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
| Synonyms: | 5-Demethylnobiletin |
| 分子量: | 388.37 |
| 分子式: | C₂₀H₂₀O₈ |
| SMILES: | O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素，一种从黄芪中分离出的多甲氧基黄酮，是5-LOX的直接抑制剂 (IC50=0.1 μM)，不影响 COX-2 的表达。5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素具有抗炎活性，抑制大鼠中性粒细胞中白三烯 B (4)(LTB4) 的形成和人嗜中性粒细胞中弹性蛋白酶的释放，IC50值为0.35 μM. |
| IC50和靶点: | [{name:"LTC4:0.35 μM (IC50)"},{name: "5-LOX:0.1 μM (IC50)"}] |
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Chiu, S.-P., Wu, M.-J., Chen, P.-Y., et al.Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cellsJ. Agric. Food Chem61(39),9453-9463(2013)
Tung, Y.-C., Li, S., Huang, Q., et al.5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone suppress lipid accumulation by activating the LKB1-AMPK pathway in 3T3-L1 preadipocytes and high fat diet-fed C57BL/6 miceJ. Agric. Food Chem64(16),3196-3205(2016)
Chang, S.N., Kim, S.H., Dey, D.K., et al.5-O-Demethylnobiletin alleviates CCL4-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy inductionInt. J. Mol. Sci.22(3),1083(2021)
Bas, E., Recio, M.C., Giner, R.M., et al.Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganumPlanta Med.72(2),136-142(2006)
