(S,R,S)-AHPC hydrochloride
Cat. No.：YN430006
CAS No. ：1448189-80-7
| 产品名称: | (S,R,S)-AHPC hydrochloride |
| CAS No.: | 1448189-80-7 |
| Chemical Name: | (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride |
| Synonyms: | VH032-NH2 hydrochloride; VHL ligand 1 hydrochloride |
| 分子量: | 467.02 |
| 分子式: | C₂₂H₃₁ClN₄O₃S |
| SMILES: | O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S,R,S)-AHPC hydrochloride 是一种基于 VH032 的，可募集 von Hippel-Lindau (VHL) 蛋白的 VHL 配体。(S,R,S)-AHPC hydrochloride 可通过 linker 与靶蛋白配体 (比如 BCR-ABL1) 连接，形成 PROTAC 分子 (比如 GMB-475)。GMB-475 作用于 Ba/F3 细胞，诱导 BCR-ABL1 降解， IC50为 1.11 μM。 |
| IC50和靶点: | |
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Raina, K., Lu, J., Qian, Y., et al.PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancerProc. Natl. Acad. Sci. USA113(26),7124-7129(2016)
Zengerle, M., Chan, K.-H., and Ciulli, A.Selective small molecule induced degradation of the BET bromodomain protein BRD4ACS Chem. Biol.10(8),1770-1777(2015)
