(S,R,S)-AHPC-Me hydrochloride
Cat. No.：YN430375
CAS No. ：1948273-03-7
| 产品名称: | (S,R,S)-AHPC-Me hydrochloride |
| CAS No.: | 1948273-03-7 |
| Chemical Name: | |
| Synonyms: | VHL ligand 2 hydrochloride; E3 ligase Ligand 1 |
| 分子量: | 481.05 |
| 分子式: | C₂₃H₃₃ClN₄O₃S |
| SMILES: | N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) 是一种基于 (S,R,S)-AHPC 的，可募集 von Hippel-Lindau (VHL) 蛋白的 VHL 配体。(S,R,S)-AHPC-Me hydrochloride 可用于合成 ARV-771。ARV-771 是一种基于 VHL E3 连接酶的 BET PROTAC 降解剂。ARV-771 可有效降解去势抵抗性前列腺癌 (CRPC) 细胞中的 BET 蛋白，DC50<1 nM |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
