Pomalidomide
Cat. No.：YN430040
CAS No. ：19171-19-8
规格
价格(RMB)
库存
| 产品名称: | Pomalidomide |
| CAS No.: | 19171-19-8 |
| Chemical Name: | 4-amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Synonyms: | 泊马度胺; CC-4047 |
| 分子量: | 273.24 |
| 分子式: | C₁₃H₁₁N₃O₄ |
| SMILES: | O=C1N(C(C2=C1C=CC=C2N)=O)C(C(N3)=O)CCC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pomalidomide 是第三代免疫调节剂，与 E3 连接酶 cereblon 相互作用，诱导必需的 Ikaros 转录因子的降解。 |
| IC50和靶点: | |
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Lopez-Girona, A., Mendy, D., Miller, K., et al.Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideLeukemia26(11),2326-2335(2012)
Zhu, Y.X., Kortuem, K.M., and Stewart, A.K.Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myelomaLeuk. Lymphoma54(4),683-687(2013)
Latif, T., Chauhan, N., Khan, R., et al.Thalidomide and its analogues in the treatment of multiple myelomaExp. Hermatol. Oncol.1(1),27(2012)
Rychak, E., Mendy, D., Shi, T., et al.Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myelomaBr. J. Haematol.172(6),889-901(2016)
