BC-1215
Cat. No.：YN430085
CAS No. ：1507370-20-8
规格
价格(RMB)
库存
| 产品名称: | BC-1215 |
| CAS No.: | 1507370-20-8 |
| Chemical Name: | N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine |
| Synonyms: | BC 1215;BC1215 |
| 分子量: | 394.51 |
| 分子式: | C₂₆H₂₆N₄ |
| SMILES: | C1(CNCCNCC2=CC=C(C3=NC=CC=C3)C=C2)=CC=C(C4=NC=CC=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BC-1215 是F-box protein 3(FBXO3) 的抑制剂，IL-1β 释放时，IC50值为 0.9 μg/mL。 BC-1215 降低 Fbxo3-Fbx12 相互作用并且阻止 SCFFbxo3催化的 Fbxl2 泛素化。 BC-1215 通过稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。BC-1215 与 ApaG 相互作用，抑制来自人 PBMC 广谱 TH1 细胞因子的分泌。 |
| IC50和靶点: | |
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Chen, B.B., Coon, T.A., Glasser, J.R., et al.A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammationNat. Immunol.14(5),470-479(2013)
Mallampalli, R.K., Coon, T.A., Glasser, J.R., et al.Targeting F box protein Fbxo3 to control cytokine-driven inflammationJ. Immunol.191(10),5247-5255(2013)
