(+)-JQ-1
Cat. No.：YN430158
CAS No. ：1268524-70-4
规格
价格(RMB)
库存
| 产品名称: | (+)-JQ-1 |
| CAS No.: | 1268524-70-4 |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl ester |
| Synonyms: | JQ1 |
| 分子量: | 456.99 |
| 分子式: | C₂₃H₂₅ClN₄O₂S |
| SMILES: | O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (+)-JQ-1 (JQ1) 是一种有效特异性的可逆BET bromodomain抑制剂，抑制BRD4(1/2)的IC50分别为 77 nM 和 33 nM。(+)-JQ-1 激活自噬 (autophagy)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
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Delmore, J.E., Issa, G.C., Lemieux, M.E., et al.BET bromodomain inhibition as a therapeutic strategy to target c-MycCell146(6),904-917(2011)
Mertz, J.A., Conery, A.R., Bryant, B.M., et al.Targeting MYC dependence in cancer by inhibiting BET bromodomainsProc. Natl. Acad. Sci. USA108(40),16669-16674(2011)
Dawson, M.A., Prinjha, R.K., Dittmann, A., et al.Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature478,529-533(2011)
