TC ASK 10
Cat. No.：YN350027
CAS No. ：1005775-56-3
| 产品名称: | TC ASK 10 |
| CAS No.: | 1005775-56-3 |
| Chemical Name: | 4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-benzamide, dihydrochloride |
| Synonyms: | TCASK 10 |
| 分子量: | 432.35 |
| 分子式: | C₂₁H₂₃Cl₂N₅O |
| SMILES: | O=C(NC1=CN2C=C(N3C=CN=C3)C=CC2=N1)C4=CC=C(C(C)(C)C)C=C4.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TC ASK 10 (Compound 10) 是一种有效的，选择性的，口服活性的细胞凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50为 14 nM。TC ASK 10 对其他代表性激酶的抑制活性低于 50％，ASK2 除外 (IC50为 0.51 μM)。 |
| IC50和靶点: | [{name:"ASK1:14 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Terao, Y., Suzuki, H., Yoshikawa, M., et al.Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitorsBioorg. Med. Chem. Lett.22(24),7326-7329(2012)
