5Z-7-Oxozeaenol
Cat. No.：YN350118
| 产品名称: | 5Z-7-Oxozeaenol |
| CAS No.: | 253863-19-3 |
| Chemical Name: | (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
| Synonyms: | FR148083; L783279; LL-Z 1640-2 |
| 分子量: | 362.37 |
| 分子式: | C₁₉H₂₂O₇ |
| SMILES: | O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2/C=C/C[C@H](O)[C@H](O)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物，为有效的，不可逆的，选择性的TAK1和VEGF-R2抑制剂，IC50值分别为 8 nM 和 52 nM。 |
| IC50和靶点: | [{name:"TAK1:8.1 nM (IC50)"},{name: "MEK1:411 nM (IC50)"},{name: "VEGFR-2:52 nM (IC50)"},{name: "VEGFR-3:110 nM (IC50)"},{name: "FLT3:170 nM (IC50)"},{name: "PDGFR-β:340 nM (IC50)"},{name: "B-RAF VE:6300 nM (IC50)"},{name: "SRC:6600 nM (IC50)"}] |
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Ninomiya-Tsuji, J., Kajino, T., Ono, K., et al.A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinaseJ. Biol. Chem.278(20),18485-18490(2003)
Choo, M.K., Kawasaki, N., Singhirunnusorn, P., et al.Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascadeMol. Cancer Ther.5(12),2970-2976(2006)
Place, D.E., Samir, P., Malireddi, R.K.S., et al.Integrated stress response restricts macrophage necroptosisLife Sci. Alliance5(1),e202101260(2021)
