GNE-3511
Cat. No.：YN350127
CAS No. ：1496581-76-0
| 产品名称: | GNE-3511 |
| CAS No.: | 1496581-76-0 |
| Chemical Name: | 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-4-pyridinecarbonitrile |
| Synonyms: | GNE3511 |
| 分子量: | 440.49 |
| 分子式: | C₂₃H₂₆F₂N₆O |
| SMILES: | N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-3511是双亮氨酸拉链激酶 (DLK)抑制剂，Ki为0.5 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Patel, S., Cohen, F., Dean, B.J., et al.Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration modelsJ. Med. Chem.58(1),401-418(2015)
