Selonsertib
Cat. No.：YN350191
CAS No. ：1448428-04-3
| 产品名称: | Selonsertib |
| CAS No.: | 1448428-04-3 |
| Chemical Name: | 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-benzamide |
| Synonyms: | GS-4997 |
| 分子量: | 445.49 |
| 分子式: | C₂₄H₂₄FN₇O |
| SMILES: | O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Selonsertib是一种选择性的，具有生物口服可利用的凋亡信号调节激酶1 (ASK1) 抑制剂，pIC50为 8.3。 |
| IC50和靶点: | [{name:"ASK1:8.3 (pIC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lanier, M., Pickens, J., Bigi, S.V., et al.Structure-based design of ASK1 inhibitors as potential agents for heart failureACS Med. Chem. Lett.8(3),316-320(2017)
Mukherjee, S., Zhelnin, L., Sanfiz, A., et al.Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotypeAm. J. Transl. Res.11(3),1531-1540(2019)
Ji, N., Yang, Y., Cai, C.-Y., et al.Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cellsCancer Lett.440-441,82-93(2018)
Lou, G., Li, A., Cen, Y., et al.Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathwayCell Biosci.11(1),9(2021)
