NQDI-1
Cat. No.：YN350197
CAS No. ：175026-96-7
| 产品名称: | NQDI-1 |
| CAS No.: | 175026-96-7 |
| Chemical Name: | 2,7-dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid, ethyl ester |
| Synonyms: | NQDI1,NQDI 1 |
| 分子量: | 319.31 |
| 分子式: | C₁₉H₁₃NO₄ |
| SMILES: | O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NQDI-1 抑制凋亡信号调节激酶 1 (ASK1)，Ki为 500 nM，IC50为 3 μM。 |
| IC50和靶点: | [{name:"ASK1:3 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Charette, S.J., Lambert, H., and Landry, J.A kinase-independent function of Ask1 in caspase-independent cell deathJ. Biol. Chem.276(39),36071-36074(2001)
Volynets, G.P., Chekanov, M.O., Synyugin, A.R., et al.Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1)J. Med. Chem.54(8),2680-2686(2011)
Yoshida, T., Ozawa, Y., Suzuki, K., et al.The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosaMol. Brain7,45(2014)
Nomura, K., Lee, M., Banks, C., et al.An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cellsNeurosci. Lett.549,163-167(2013)
