GNE-495
Cat. No.：YN350004
CAS No. ：1449277-10-4
| 产品名称: | GNE-495 |
| CAS No.: | 1449277-10-4 |
| Chemical Name: | 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide |
| Synonyms: | GNE-495;GNE 495;8-Amino-N-[1-(Cyclopropylcarbonyl)azetidin-3-Yl]-2-(3-Fluorophenyl)-1,7-Naphthyridine-5-Carboxamide;8-amino-N-[1-(cyclopropanecarbonyl)azetidin-3-yl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide;8-amino-N-(1-(cyclopropanecarbonyl)aze |
| 分子量: | 405.42 |
| 分子式: | C₂₂H₂₀FN₅O₂ |
| SMILES: | O=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-495 是有效，选择性的MAP4K4抑制剂，IC50值3.7 nM。 |
| IC50和靶点: | [{name:"MAP4K4:3.7 nM (IC50)"}] |
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| Solvent & Solubility: |
Ndubako, C.O., Crawford, T.D., Chen, H., et al.Structure-based design of GNE-495, a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesisACS Med. Chem. Lett.6(8),913-918(2015)
Vitorino, O., Yeung, S., Crow, A., et al.MAP4K4 regulates integrin-FERM binding to control endothelial cell motilityNature519(7544),425-430(2015)
