DMX-5804
Cat. No.：YN350072
CAS No. ：2306178-56-1
| 产品名称: | DMX-5804 |
| CAS No.: | 2306178-56-1 |
| Chemical Name: | |
| Synonyms: | DMX-5084 |
| 分子量: | 361.39 |
| 分子式: | C₂₁H₁₉N₃O₃ |
| SMILES: | O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DMX-5804 是一种有效、可口服、选择性的MAP4K4抑制剂，对人 MAP4K4 的IC50值为 3 nM，pIC50值为 8.55；对 MINK1/MAP4K6 (pIC50，8.18) 和 TNIK/MAP4K7 (pIC50，7.96) 的作用相对较弱。DMX-5804 能够增强心肌细胞存活率，减少小鼠的缺血再灌注损伤。 |
| IC50和靶点: | [{name:"MAP4K4:3 nM (IC50)"},{name: "MAP4K4:8.55 (pIC50)"},{name: "MINK1/MAP4K6:8.18 (pIC50)"},{name: "TNIK/MAP4K7:7.96 (pIC50)"},{name: "GCK/MAP4K2:6.50 (pIC50)"},{name: "KHS/MAP4K5:6.36 (pIC50)"},{name: "GLK/MAP4K3:4.95 (pIC50)"},{name: "MLK1/MAP3K9:7.19 (pIC50)"},{name: "MLK3/MAP3K11:6.99 (pIC50)"},{name: "NUAK:6.88 (pIC50)"},{name: "VEGFR:5.72 (pIC50)"},{name: "ABL1:5.80 (pIC50)"},{name: "Aurora B:5.49 (pIC50)"},{name: "FLT3:5.31 (pIC50)"},{name: "GSK3β:4.66 (pIC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
