KY-05009
Cat. No.：YN350111
CAS No. ：1228280-29-2
| 产品名称: | KY-05009 |
| CAS No.: | 1228280-29-2 |
| Chemical Name: | 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide |
| Synonyms: | 5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide |
| 分子量: | 352.41 |
| 分子式: | C₁₈H₁₆N₄O₂S |
| SMILES: | O=C(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KY-05009 是一种具有 ATP 竞争性的TNIK抑制剂，Ki为 100 nM。KY-05009 在药理上抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK的蛋白表达和Wnt靶基因的转录活性，并诱导癌细胞凋亡。KY-05009 具有抗癌活性。 |
| IC50和靶点: | [{name:"TNIK:100 nM (Ki)"}] |
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Kim, J., Moon, S.H., Kim, B.T., et al.A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cellsPLoS One9(10),e110180(2014)
Lee, Y., Jung, J.I., Park, K.Y., et al.Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cellsOncotarget8(25),41091-41101(2017)
