WR-1065 dihydrochloride
Cat. No.:YN270054
产品名称: | WR-1065 dihydrochloride |
CAS No.: | 14653-77-1 |
Chemical Name: | 2-[(3-aminopropyl)amino]-ethanethiol, dihydrochloride |
Synonyms: | WR 1065,硫代乙基氨基乙基胺盐酸盐 |
分子量: | 207.16 |
分子式: | C₅H₁₆Cl₂N₂S |
SMILES: | NCCCNCCS.Cl.Cl |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | WR-1065 dihydrochloride 可以保护正常组织免受某些癌症药物的毒性作用,并通过 JNK 依赖性信号通路激活p53。 |
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Shaw, L.M., Bonner, H., and Lieberman, R.Pharmacokinetic profile of amifostineSemin. Oncol.23(4 Suppl 8),18-22(1996)
Walker, R.B., and Everette, J.D.Comparative reaction rates of various antioxidants with ABTS radical cationJ. Agric. Food Chem.57(4),1156-1161(2009)
Grdina, D.J., and Nagy, B.The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cellsBr. J. Cancer54(6),933-941(1986)
Sigdestad, C.P., Treacy, S.H., Knapp, L.A., et al.The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cellsBr. J. Cancer55(5),477-482(1987)
Grdina, D.J., Nagy, B., Hill, C.K., et al.The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cellsCarcinogenesis6(6),929-931(1985)
Nagy, B., Dale, P.J., and Grdina, D.J.Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiolCancer Res.46(3),1132-1135(1986)
Pamujula, S., Kishore, V., Rider, B., et al.Radioprotection in mice following oral administration of WR-1065/ PLGA nanoparticlesInt. J. Radiat. Biol.84(11),900-908(2008)