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WR-1065 dihydrochloride

Cat. No.:YN270054

  • CAS No. :14653-77-1

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    • 产品名称: WR-1065 dihydrochloride
      CAS No.: 14653-77-1
      Chemical Name: 2-[(3-aminopropyl)amino]-ethanethiol, dihydrochloride
      Synonyms:WR 1065,硫代乙基氨基乙基胺盐酸盐
      分子量:207.16
      分子式:C₅H₁₆Cl₂N₂S
      SMILES:NCCCNCCS.Cl.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: WR-1065 dihydrochloride 可以保护正常组织免受某些癌症药物的毒性作用,并通过 JNK 依赖性信号通路激活p53。
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    • Shaw, L.M., Bonner, H., and Lieberman, R.Pharmacokinetic profile of amifostineSemin. Oncol.23(4 Suppl 8),18-22(1996)

      Walker, R.B., and Everette, J.D.Comparative reaction rates of various antioxidants with ABTS radical cationJ. Agric. Food Chem.57(4),1156-1161(2009)

      Grdina, D.J., and Nagy, B.The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cellsBr. J. Cancer54(6),933-941(1986)

      Sigdestad, C.P., Treacy, S.H., Knapp, L.A., et al.The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cellsBr. J. Cancer55(5),477-482(1987)

      Grdina, D.J., Nagy, B., Hill, C.K., et al.The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cellsCarcinogenesis6(6),929-931(1985)

      Nagy, B., Dale, P.J., and Grdina, D.J.Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiolCancer Res.46(3),1132-1135(1986)

      Pamujula, S., Kishore, V., Rider, B., et al.Radioprotection in mice following oral administration of WR-1065/ PLGA nanoparticlesInt. J. Radiat. Biol.84(11),900-908(2008)

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