NSC 146109 hydrochloride
Cat. No.：YN270085
| 产品名称: | NSC 146109 hydrochloride |
| CAS No.: | 59474-01-0 |
| Chemical Name: | carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride |
| Synonyms: | NSC 146109 (hydrochloride)；XI-011 |
| 分子量: | 316.85 |
| 分子式: | C₁₇H₁₇ClN₂S |
| SMILES: | [H]Cl.NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC 146109 hydrochloride 是一种小分子p53活化剂，其靶向MDMX，对乳腺癌中有潜在研究作用具有价值。_x000D_NSC 146109 hydrochloride 是假尿嘧啶衍生物，通过激活 p53 并诱导促凋亡基因的表达促进乳腺癌细胞发生凋亡 (apoptosis)。 |
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Wang, W., Kim, S.H., and El-Deiry, W.S.Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenograftsProc. Natl. Acad. Sci. USA103(29),11003-11008(2006)
Wang, H., and Yan, C.A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cellsNeoplasia13(7),611-619(2011)
Roh, J.L., Park, J.Y., and Kim, E.H.XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancerApoptosis19(11),1594-1602(2014)
