SP-141
Cat. No.：YN270094
CAS No. ：1253491-42-7
| 产品名称: | SP-141 |
| CAS No.: | 1253491-42-7 |
| Chemical Name: | 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Synonyms: | SP 141 |
| 分子量: | 324.38 |
| 分子式: | C₂₂H₁₆N₂O |
| SMILES: | COC1=CC2=C(NC3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SP-141 是一种特异性的MDM2抑制剂。SP-141 促进 MDM2 自泛素化和降解。SP-141 可用于胰腺癌和乳腺癌的研究。 |
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Vassilev, L.T., Vu, B.T., Graves, B., et al.In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Science303(5659),844-848(2004)
Wang, W., Qin, J.J., Voruganti, S., et al.The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer modelsNat. Commun.5,1-12(2014)
Wang, W., Qin, J.J., Voruganti, S., et al.Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in miceGastroenterology147(4),893-902(2014)
Nag, S., Qin, J.J., Voruganti, S., et al.Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in miceBiomed. Chromatogr.29(5),654-663(2015)
