RITA
Cat. No.：YN270226
| 产品名称: | RITA |
| CAS No.: | 213261-59-7 |
| Chemical Name: | 5,5'-(2,5-furandiyl)bis-2-thiophenemethanol |
| Synonyms: | NSC 652287 |
| 分子量: | 292.37 |
| 分子式: | C₁₄H₁₂O₃S₂ |
| SMILES: | OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RITA 是一种有效的p53-HDM-2相互作用抑制剂，可与 p53dN 结合，Kd值为 1.5 nM，同时能够诱导DNA-DNA交联。 |
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Chène, P.Inhibiting the p53-MDM2 interaction: An important target for cancer therapyNat. Rev. Cancer3,102-109(2003)
Issaeva, N., Bozko, P., Enge, M., et al.Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activities p53 function in tumorsNat. Med.10(12),1321-1328(2004)
Rivera, M.I., Stinson, S.F., Vistica, D.T., et al.Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines. Differential accumulation and metabolismBiochem. Pharmacol.57(11),1283-1295(1999)
