NSC 66811
Cat. No.：YN270294
| 产品名称: | NSC 66811 |
| CAS No.: | 6964-62-1 |
| Chemical Name: | 2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol |
| Synonyms: | NSC 66811, NSC66811, NSC-66811 |
| 分子量: | 340.42 |
| 分子式: | C₂₃H₂₀N₂O |
| SMILES: | OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC 66811 是一个MDM2-p53抑制剂，其结合到MDM2 的Ki值为 120 nM。 |
| IC50和靶点: | |
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Lu, Y., Nikolovska-Coleska, Z., Fang, X., et al.Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategyJ. Med. Chem.49(13),3759-3762(2006)
Shangary, S., and Wang, S.Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapyAnnu. Rev. Pharmacol. Toxicol.49,223-241(2016)
