PK11000
Cat. No.：YN270617
CAS No. ：38275-34-2
| 产品名称: | PK11000 |
| CAS No.: | 38275-34-2 |
| Chemical Name: | 5-chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid |
| Synonyms: | PK 11000，PK-11000，PK11000 |
| 分子量: | 236.63 |
| 分子式: | C₆H₅ClN₂O₄S |
| SMILES: | O=C(C1=NC(S(=O)(C)=O)=NC=C1Cl)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型p53的 DNA 结合结构域，而不影响 DNA 的结合。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bauer, M.R., Joerger, A.C., and Fersht, A.R.2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cellsProc. Natl. Acad. Sci. U S A113(36),E5271-E5280(2016)
