PD0325901
Cat. No.：YN350022
| 产品名称: | PD0325901 |
| CAS No.: | 391210-10-9 |
| Chemical Name: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Synonyms: | PD325901 |
| 分子量: | 482.19 |
| 分子式: | C₁₆H₁₄F₃IN₂O₄ |
| SMILES: | O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2F)F)NOC[C@H](O)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD0325901 (PD325901) 是一种具有口服活性，选择性和非 ATP 竞争性的MEK抑制剂，IC50为 0.33 nM。PD0325901 对活化的 MEK1 和 MEK2 的Kiapp值为 1 nM。PD0325901 抑制 p-ERK1/2 的表达并诱导细胞凋亡 (apoptosis)。PD0325901 对多种人类肿瘤异种移植物具有抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
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