Trametinib
Cat. No.：YN350063
CAS No. ：871700-17-3
| 产品名称: | Trametinib |
| CAS No.: | 871700-17-3 |
| Chemical Name: | N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide |
| Synonyms: | 曲美替尼; GSK1120212; JTP-74057 |
| 分子量: | 615.39 |
| 分子式: | C₂₆H₂₃FIN₅O₄ |
| SMILES: | CC(NC1=CC=CC(N(C2=O)C(C(C(N2C3CC3)=O)=C(N4C)NC5=CC=C(C=C5F)I)=C(C4=O)C)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trametinib (GSK1120212; JTP-74057) 是口服有效的MEK抑制剂，抑制 MEK1 和 MEK2 的IC50分别为 2 nM。Trametinib 可以激活自噬 (autophagy)，诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"MEK1:2 nM (IC50)"},{name: "MEK2:2 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Yamaguchi, T., Kakefuda, R., Tajima, N., et al.Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivoInt. J. Oncol.39(1),23-31(2011)
Yamaguchi, T., Kakefuda, R., Tanimoto, A., et al.Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: A comparison with leflunomideInflamm. Res.61(5),445-454(2012)
