Trametinib (DMSO solvate)
Cat. No.：YN350064
CAS No. ：1187431-43-1
| 产品名称: | Trametinib (DMSO solvate) |
| CAS No.: | 1187431-43-1 |
| Chemical Name: | Trametinib dimethyl sulfoxide; Trametinib dimethyl sulfoxide solvate; GSK 1120212B; JTP-74057 DMSO solvate |
| Synonyms: | GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate) |
| 分子量: | 693.53 |
| 分子式: | C₂₈H₂₉FIN₅O₅S |
| SMILES: | CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) 是口服有效的MEK抑制剂，抑制 MEK1 和 MEK2 的IC50分别为 2 nM。Trametinib (DMSO solvate) 可以激活自噬 (autophagy)，诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"MEK1:2 nM (IC50)"},{name: "MEK2:2 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Abe, H., et al.: ACS Med. Chem. Lett., 2, 320 (2011)
