U0126
Cat. No.：YN350094
| 产品名称: | U0126 |
| CAS No.: | 109511-58-2 |
| Chemical Name: | 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile |
| Synonyms: | U 0126,U-0126 |
| 分子量: | 380.49 |
| 分子式: | C₁₈H₁₆N₆S₂ |
| SMILES: | NC1=CC=CC=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=CC=CC=C2N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | U0126 是一种有效，非 ATP 竞争性的，选择性的MEK1和MEK2抑制剂，IC50分别为 72 nM 和 58 nM。U0126-EtOH 是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 抑制剂。 |
| IC50和靶点: | [{name:"MEK2:60 nM (IC50)"},{name: "MEK1:70 nM (IC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Favata, M.F., Horiuchi, K.Y., Manos, E.J., et al.Identification of a novel inhibitor of mitogen-activated protein kinase kinaseJ. Biol. Chem.273(29),18623-18632(1998)
Dokladda, K., Green, K.A., Pan, D.A., et al.PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathwayFEBS Lett.579(1),236-240(2005)
