Pimasertib
Cat. No.：YN350096
CAS No. ：1236699-92-5
| 产品名称: | Pimasertib |
| CAS No.: | 1236699-92-5 |
| Chemical Name: | N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide |
| Synonyms: | AS703026; MSC1936369B |
| 分子量: | 431.20 |
| 分子式: | C₁₅H₁₅FIN₃O₃ |
| SMILES: | FC1=C(C=CC(I)=C1)NC2=CN=CC=C2C(NC[C@@H](CO)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimasertib (AS703026) 是一种高效，具有选择性，ATP 非竞争性的MEK1/2别构抑制剂，主要用于癌症研究。 |
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VanScyoc, W.S., Holdgate, G.A., Sullivan, J.E., et al.Enzyme kinetics and binding studies on inhibitors of MEK protein kinaseBiochemistry47,5017-5027(2008)
Kim, K., Kong, S.Y., Fulciniti, M., et al.Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivoBr. J. Haematol.149(4),537-549(2010)
Yoon, J., Koo, K.H., and Choi, K.Y.MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapyCancer Res.71,445-453(2011)
