PD318088
Cat. No.：YN350103
CAS No. ：391210-00-7
| 产品名称: | PD318088 |
| CAS No.: | 391210-00-7 |
| Chemical Name: | 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Synonyms: | PD 318088; PD-318088 |
| 分子量: | 561.09 |
| 分子式: | C₁₆H₁₃BrF₃IN₂O₄ |
| SMILES: | BrC1=CC(C(NOCC(CO)O)=O)=C(C(F)=C1F)NC2=CC=C(C=C2F)I |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD318088 是一种有效的、变构的、非 ATP 竞争性的MEK1/2抑制剂，PD184352 (HY-50295) 的结构类似物。PD318088 在MEK1 活性位点与 ATP 结合位点相邻的区域与 ATP 同时结合。PD318088 可用于癌症研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ohren, J.F., Chen, H., Pavlovsky, A., et al.Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibitionNat. Struct. Mol. Biol.11(12),1192-1197(2004)
Shang, J., Lu, S., Jiang, Y., et al.Allosteric modulators of MEK1: Drug design and discoveryChem. Biol. Drug Des.88(4),485-497(2016)
