TAK-733
Cat. No.：YN350137
CAS No. ：1035555-63-5
| 产品名称: | TAK-733 |
| CAS No.: | 1035555-63-5 |
| Chemical Name: | 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione |
| Synonyms: | TAK733,TAK 733 |
| 分子量: | 504.23 |
| 分子式: | C₁₇H₁₅F₂IN₄O₄ |
| SMILES: | O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAK-733 是一种有效的选择性MEK抑制剂，IC50为 3.2 nM。 |
| IC50和靶点: | [{name:"MEK:3.2 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dong, Q., Dougan, D.R., Gong, X., et al.Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancerBioorg. Med. Chem. Lett.21(5),1315-1319(2011)
Cowan, K.J., and Storey, K.B.Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stressJ. Exp. Biol.206(Pt 7),1107-1115(2003)
von Euw, E., Atefi, M., Attar, N., et al.Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell linesMol. Cancer11,22(2012)
