RO4987655
Cat. No.：YN350150
| 产品名称: | RO4987655 |
| CAS No.: | 874101-00-5 |
| Chemical Name: | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(tetrahydro-3-oxo-2H-1,2-oxazin-2-yl)methyl]-benzamide |
| Synonyms: | CH4987655 |
| 分子量: | 565.28 |
| 分子式: | C₂₀H₁₉F₃IN₃O₅ |
| SMILES: | FC(C(F)=C(NC1=CC=C(I)C=C1F)C(C(NOCCO)=O)=C2)=C2CN3C(CCCO3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RO4987655 是一种具有口服活性的选择性MEK抑制剂，抑制MEK1/MEK2，IC50为 5.2 nM。 |
| IC50和靶点: | [{name:"MEK1:5.2 nM (IC50)"},{name: "MEK2:5.2 nM (IC50)"}] |
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| Solvent & Solubility: |
Isshiki, Y., Kohchi, Y., Iikura, H., et al.Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agentBioorg. Med. Chem. Lett.21(6),1795-1801(2011)
