Ro 5126766
Cat. No.：YN350185
CAS No. ：946128-88-7
| 产品名称: | Ro 5126766 |
| CAS No.: | 946128-88-7 |
| Chemical Name: | N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N′-methyl-sulfamide |
| Synonyms: | CH5126766 |
| 分子量: | 471.46 |
| 分子式: | C₂₁H₁₈FN₅O₅S |
| SMILES: | O=S(NC)(NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 5126766 (CH5126766) 是一种有效的双重MEK/RAF抑制剂，抑制BRAFV600E，CRAF,MEK，和BRAF，IC50分别为 8.2 nM, 56 nM, 160 nM 和 190 nM。 |
| IC50和靶点: | [{name:"MEK:160 nM (IC50)"},{name: "BRafV600E:8.2 nM (IC50)"},{name: "Braf:190 nM (IC50)"},{name: "CRAF:56 nM (IC50)"}] |
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| Solvent & Solubility: |
Ishii, N., Harada, N., Joseph, E.W., et al.Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activityCancer Res.73(13),4050-4060(2013)
Wada, M., Horinaka, M., Yamazaki, T., et al.The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cellsPLoS ONE9(11),e113217(2014)
