CI-1040
Cat. No.：YN350208
CAS No. ：212631-79-3
| 产品名称: | CI-1040 |
| CAS No.: | 212631-79-3 |
| Chemical Name: | 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
| Synonyms: | PD 184352 |
| 分子量: | 478.66 |
| 分子式: | C₁₇H₁₄ClF₂IN₂O₂ |
| SMILES: | O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CI-1040 (PD 184352) 是有口服活性，高度特异的MEK小分子抑制剂，对 MEK1 的IC50值为 17 nM 。 |
| IC50和靶点: | [{name:"MEK1:17 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
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Barret, S.D., Bridges, A.J., Dudley, D.T., et al.The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901Bioorg. Med. Chem. Lett.18,6501-6504(2008)
VanScyoc, W.S., Holdgate, G.A., Sullivan, J.E., et al.Enzyme kinetics and binding studies on inhibitors of MEK protein kinaseBiochemistry47,5017-5027(2008)
