OTSSP167 hydrochloride
Cat. No.：YN420217
CAS No. ：1431698-10-0
规格
价格(RMB)
库存
| 产品名称: | OTSSP167 hydrochloride |
| CAS No.: | 1431698-10-0 |
| Chemical Name: | 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-one, monohydrochloride |
| Synonyms: | OTSSP 167 盐酸盐 |
| 分子量: | 523.88 |
| 分子式: | C₂₅H₂₉Cl₃N₄O₂ |
| SMILES: | ClC1=CC(C2=CC=C(N=CC(C(C)=O)=C3N[C@H]4CC[C@H](CN(C)C)CC4)C3=N2)=CC(Cl)=C1O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OTSSP167 hydrochloride 是一种高效的MELK抑制剂，IC50值为 0.41 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jiang, P., and Zhang, D.Maternal embryonic leucine zipper kinase (MELK): A novel regulator in cell cycle control, embryonic development, and cancerInt. J. Mol. Sci.14(11),21551-21560(2013)
Gray, D., Jubb, A.M., Hogue, D., et al.Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancersCancer Res.65(21),9751-9761(2005)
Joshi, K., Banasavadi-Siddegowda, Y., Mo, X., et al.MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cellsStem Cells31(6),1051-1063(2013)
Nakano, I., Joshi, K., Visnyei, K., et al.Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathwayNeuro. Oncol.13(6),622-634(2011)
Chung, S., Suzuki, H., Miyamoto, T., et al.Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancerOncotarget3(12),1629-1640(2012)
Chung, S., and Nakamura, Y.MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cellsCell Cycle12(11),1655-1656(2013)
