ETC-206
Cat. No.：YN350082
CAS No. ：1464151-33-4
| 产品名称: | ETC-206 |
| CAS No.: | 1464151-33-4 |
| Chemical Name: | 4-[6-[4-(4-morpholinylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]-benzonitrile |
| Synonyms: | ETC-1907206 |
| 分子量: | 408.45 |
| 分子式: | C₂₅H₂₀N₄O₂ |
| SMILES: | N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=CN32)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ETC-206 是一种选择性MNK1和MNK2抑制剂，IC50分别为 64 nM 和 86 nM。 |
| IC50和靶点: | [{name:"MNK1:64 nM (IC50)"},{name: "MNK2:86 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yang, H., Chennamaneni, L.R., Ho, M.W.T., et al.Optimization of selective mitogen-activated protein kinase interacting kinases 1 and 2 inhibitors for the treatment of blast crisis leukemiaJ. Med. Chem.61(10),4348-4369(2018)
Sandeman, L.Y., Kang, W.X., Wang, X., et al.Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesityMol. Metab.42,101054(2020)
