Cercosporamide
Cat. No.：YN350181
CAS No. ：131436-22-1
| 产品名称: | Cercosporamide |
| CAS No.: | 131436-22-1 |
| Chemical Name: | (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide |
| Synonyms: | 4-Dibenzofurancarboxamide,8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-, (9aS)-;Cercosporamide;(-)-Cercosporamide;(9aS)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamide;4-Dibenzofurancarboxamide;Cercosporamide from Cercosporid |
| 分子量: | 331.28 |
| 分子式: | C₁₆H₁₃NO₇ |
| SMILES: | O=C(C1=C(C([C@@]23C)=C(O)C=C1O)OC2=CC(O)=C(C(C)=O)C3=O)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cercosporamide 是一种高效的 ATP 竞争性Pkc1激酶抑制剂，IC50 sub><50 nM，Ki<7 nM。Cercosporamide 是一种独特的Mnk抑制剂。 |
| IC50和靶点: | [{name:"Pkc1:50 nM (IC50)"},{name: "Pkc1:7 nM (Ki)'}, 'Mnk'] |
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| Solvent & Solubility: |
Sugawara, F., Strobel, S., Strobel, G., et al.The structure and biological activity of cercosporamide from Cercosporidium henningsiiJ. Org. Chem.56(3),909-910(1991)
Sussman, A., Huss, K., Chio, L.C., et al.Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screeningEukaryot. Cell3(4),932-943(2004)
Furukawa, A., Arita, T., Satoh, S., et al.(-)-Cercosporamide derivatives as novel antihyperglycemic agentsBioorg. Med. Chem. Lett.19(3),724-726(2009)
Konicek, B.W., Stephens, J.R., McNulty, A.M., et al.Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastasesCancer Res.71(5),1849-1857(2011)
Hou, J., Lam, F., Proud, C., et al.Targeting Mnks for cancer therapyOncotarget3(2),118-131(2012)
