JNJ-10229570
Cat. No.：YN320315
CAS No. ：524923-88-4
| 产品名称: | JNJ-10229570 |
| CAS No.: | 524923-88-4 |
| Chemical Name: | N-[2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]-benzenamine |
| Synonyms: | JNJ10229570,JNJ 10229570,UNII-N9IX402L35 |
| 分子量: | 389.47 |
| 分子式: | C₂₂H₁₉N₃O₂S |
| SMILES: | COC1=C(C=CC=C1)C(N(C2=C(C=CC=C2)OC)S/3)=NC3=N\C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-10229570 是肾上腺皮质受体 1(MC1R)和肾上腺皮质受体 5(MC5R)的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的IC50值分别为 270 nM 和 200 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Eisinger, M., Li, W.-H., Anthonavage, M., et al.A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipidsJ. Dermatol. Sci.63(1),23-32(2011)
