2-Iodomelatonin
Cat. No.：YN320104
CAS No. ：93515-00-5
| 产品名称: | 2-Iodomelatonin |
| CAS No.: | 93515-00-5 |
| Chemical Name: | N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Synonyms: | 2-碘褪黑激素 |
| 分子量: | 358.17 |
| 分子式: | C₁₃H₁₅IN₂O₂ |
| SMILES: | CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 2-Iodomelatonin 是褪黑激素受体 1 (MT1) 的强效激动剂，Ki为 28 pM，对 MT1的选择性是 MT2 的 5 倍以上。2-Iodomelatonin 可用于鉴定，表征和定位脑和周围组织的褪黑激素结合位点。 |
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Dubocovich, M.L., Masana, M.I., Iacob, S., et al.Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptorNaunyn-Schmiedeberg's Arch. Pharmacol.355(3),365-375(1997)
Browning, C., Beresford, I., Fraser, N., et al.Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptorsBr. J. Pharmacol.129(5),877-886(2000)
Cecon, E., Chen, M., Marçola, M., et al.Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathwayFASEB J.29(6),2566-2582(2015)
Adamah-Biassi, E.B., Zhang, Y., Jung, H., et al.Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic miceJ. Histochem. Cytochem.62(1),70-84(2014)
