8-M-PDOT
Cat. No.：YN320135
CAS No. ：134865-70-6
| 产品名称: | 8-M-PDOT |
| CAS No.: | 134865-70-6 |
| Chemical Name: | N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-propanamide |
| Synonyms: | AH-002 |
| 分子量: | 233.31 |
| 分子式: | C₁₄H₁₉NO₂ |
| SMILES: | CCC(NC1CC2=C(C=CC=C2OC)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-M-PDOT (AH-002) 是一种选择性的褪黑激素MT2受体激动剂。8-M-PDOT 对MT2的选择性是 MT1 受体的 5.2 倍。8-M-PDOT 结合人类重组 MT1 和MT2受体，其pKi值分别为 8.23 和 8.95。8-M-PDOT 具有抗焦虑活性。 |
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Browning, C., Beresford, I., Fraser, N., et al.Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptorsBr. J. Pharmacol.129(5),877-886(2000)
Noseda, A.C., Targa, A.D., Rodrigues, L.S., et al.REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effectsSleep Sci.9(1),47-54(2016)
