Ramelteon
Cat. No.：YN321325
CAS No. ：196597-26-9
| 产品名称: | Ramelteon |
| CAS No.: | 196597-26-9 |
| Chemical Name: | N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-propanamide |
| Synonyms: | 雷美替胺; TAK-375 |
| 分子量: | 259.34 |
| 分子式: | C₁₆H₂₁NO₂ |
| SMILES: | O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ramelteon是高效选择性的melatonin受体激动剂，结合人melatonin1和melatonin2受体的Ki值分别为14 和112 pM。 |
| IC50和靶点: | |
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Kato, K., Hirai, K., Nishiyama, K., et al.Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonistNeuropharmacology48(2),301-310(2005)
Yukuhiro, N., Kimura, H., Nishikawa, H., et al.Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeysBrain Res.1027(1-2),59-66(2004)
Hirai, K., Kita, M., Ohta, H., et al.Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in ratsJ. Biol. Rhythms20(1),27-37(2005)
