NAPQI
Cat. No.：YN1720068
| 产品名称: | NAPQI |
| CAS No.: | 50700-49-7 |
| Chemical Name: | N-(4-oxo-2,5-cyclohexadien-1-ylidene)-acetamide |
| Synonyms: | N-ACETYL-4-BENZOQUINONE IMINE;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide,N-Acetyl-p-benzo-quinoneimine,NAPQI;N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide;NAPQI;N-Acetyl-1,4-benzoquinonimine;N-Acetyl-p-b |
| 分子量: | 149.2 |
| 分子式: | C8H7NO2 |
| SMILES: | O=C(C=C/1)C=CC1=N\C(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NAPQI 是Acetaminophen(HY-66005) 的毒性代谢物。NAPQI 也是维生素 K 循环中酶的抑制剂。NAPQI 能被谷胱甘肽 (GSH) 迅速解毒，但在 GSH 缺乏的情况下，过量的 NAPQI 与蛋白质中的半胱氨酸残基反应，导致细胞死亡和肝脏毒性。 |
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Qiu, Y., Benet, L.Z., and Burlingame, A.L.Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometryJ. Biol. Chem.273(28),17940-17953(1998)
