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16α-Hydroxyestrone

Cat. No.:YN1720070

  • CAS No. :566-76-7

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    • 参考文献
    • 产品名称: 16α-Hydroxyestrone
      CAS No.: 566-76-7
      Chemical Name: 3,16α-dihydroxy-estra-1,3,5(10)-trien-17-one
      Synonyms:16αOHE
      分子量:286.4
      分子式:C18H22O3
      SMILES:O=C1[C@H](O)C[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 16α-Hydroxyestrone (16αOHE) 是雌二醇的主要代谢物。16α-Hydroxyestrone (16αOHE) 可以用来研究代谢性疾病。
      IC50和靶点:
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    • Gruber, C.J., Tschugguel, W., Schneeberger, C., et al.Production and actions of estrogensN. Engl. J. Med.346(5),340-352(2002)

      Cutolo, M., Sulli, A., and Straub, R.H.Estrogen metabolism and autoimmunityAutoimmun. Rev.11(6-7),A460-A464(2012)

      Matthews, C.E., Fortner, R.T., Xu, X., et al.Association between physical activity and urinary estrogens and estrogen metabolites in premenopausal womenJ. Clin. Endocrinol. Metab.97(10),3724-3733(2012)

      Obi, N., Wrieling, A., Heinz, J., et al.Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer?Int. J. Womens Health3,37-51(2011)

      Swaneck, G.E., and Fishman, J.Covalent binding of the endogenous estrogen 16α-hydroxyestrone to estradiol receptor in human breast cancer cells: Characterization and intranuclear localizationProc. Natl. Acad. Sci. USA85(21),7831-7835(1988)

      Mackey, R.H., Fanelli, T.J., Modugno, F., et al.Hormone therapy, estrogen metabolism, and risk of breast cancer in the women's health initiative hormone therapy trialCancer Epidemiol. Biomarkers Prev.21(11),2022-2032(2012)

      Okobia, M.N., and Bunker, C.H.Estrogen metabolism and breast cancer risk: A reviewAfr. J. Reprod. Health10(1),13-25(2006)

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