Pironetin
Cat. No.：YN290150
| 产品名称: | Pironetin |
| CAS No.: | 151519-02-7 |
| Chemical Name: | (5R,6R)-5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-2H-pyran-2-one |
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| 分子量: | 324.45 |
| 分子式: | C₁₉H₃₂O₄ |
| SMILES: | O=C1C=C[C@H]([C@H](O1)C[C@H]([C@@H]([C@@H]([C@H](C/C=C/C)C)OC)C)O)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pironetin 是从链霉菌属物种分离的 α/β 不饱和内酯。Pironetin 与α-tubulin结合，是微管聚合的有效抑制剂，具有细胞周期停滞和抗肿瘤活性。 |
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Kobayashi, S., Tsuchiya, K., Harada, T., et al.Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK10958. I. Taxonomy, production, isolation and preliminary characterizationJ. Antibiot. (Tokyo)47(6),697-702(1994)
Kondoh, M., Usui, T., Nishikiori, T., et al.Apoptosis induction via microtubule disassembly by an antitumour compound, pironetinBiochem. J.340(Pt 2),411-416(1999)
Vilanova, C., Díaz-Oltra, S., Murga, J., et al.Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulinJ. Med. Chem.57(24),10391-10403(2014)
Yasui, K., Tamura, Y., Nakatani, T., et al.Chemical modification of PA-48153C, a novel immunosuppressant isolated from Streptomyces prunicolor PA-48153J. Antibiot. (Tokyo)49(2),173-180(1996)
Kondoh, M., Usui, T., Kobayashi, S., et al.Cell cycle arrest and antitumor activity of pironetin and its derivativesCancer Lett.126(1),29-32(1998)
