Thiocolchicine
Cat. No.：YN290151
CAS No. ：2730-71-4
| 产品名称: | Thiocolchicine |
| CAS No.: | 2730-71-4 |
| Chemical Name: | N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide |
| Synonyms: | Thiocolchicine. |
| 分子量: | 415.50 |
| 分子式: | C₂₂H₂₅NO₅S |
| SMILES: | CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thiocolchicine 是秋水仙碱 (HY-16569) 的衍生物，是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂(IC50=2.5 µM)，其Ki值为 0.7 µM 竞争性结合微管蛋白。Thiocolchicine 可以作为ADC的毒素分子。 |
| IC50和靶点: | |
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Hahn, K.M., Humphreys, W.G., Helms, A.M., et al.Structural requirements for the binding of colchicine analogs to tubulin: The role of the C-10 substituentBioor. Med. Chem. Lett.1(9),471-476(1991)
De Vincenzo, R., Scambia, G., Ferlini, C., et al.Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell linesAnticancer Drug Des.12(1),19-33(1998)
