Verubulin hydrochloride
Cat. No.：YN290173
CAS No. ：917369-31-4
| 产品名称: | Verubulin hydrochloride |
| CAS No.: | 917369-31-4 |
| Chemical Name: | N-(4-methoxyphenyl)-N,2-dimethyl-4-quinazolinamine, monohydrochloride |
| Synonyms: | MPC-6827 hydrochloride |
| 分子量: | 315.80 |
| 分子式: | C₁₇H₁₈ClN₃O |
| SMILES: | CC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Verubulin hydrochloride (MPC-6827 hydrochloride) 是一种可透过血脑屏障的微管阻断剂，具有强效广谱的体内外细胞毒活性。在人 MX-1 乳腺癌和其他小鼠异种移植瘤模型中，Verubulin hydrochloride 表现出高效的抗癌活性，可用于多种癌症的研究。 |
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Kasibhatla, S., Baichwal, V., Cai, S.X., et al.MPC-6827: A small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumpsCancer. Res.67(12),5865-5871(2007)
Sirisoma, N., Pervin, A., Zhang, H., et al.Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetrationJ. Med. Chem.52(8),2341-2351(2009)
