4'-Demethylepipodophyllotoxin
Cat. No.：YN290417
| 产品名称: | 4'-Demethylepipodophyllotoxin |
| CAS No.: | 6559-91-7 |
| Chemical Name: | (5R,5aR,8aR,9S)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| Synonyms: | 4'-去甲基表鬼臼毒素; 4'-O-demethylepipodophyllotoxin; 4'-DMEP |
| 分子量: | 400.38 |
| 分子式: | C₂₁H₂₀O₈ |
| SMILES: | O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4'-Demethylepipodophyllotoxin(4'-DMEP)是一个中间体化合物，能抑制微管组装。 |
| IC50和靶点: | |
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Daley, L., Guminski, Y., Demerseman, P., et al.Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611J. Med. Chem.41(23),4475-4485(1998)
Zhao, W., Chen, L., Li, H.-M., et al.A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenationBioorg. Med. Chem.22(11),2998-3007(2014)
