J-147
Cat. No.：YN380085
| 产品名称: | J-147 |
| CAS No.: | 1146963-51-0 |
| Chemical Name: | 2,2,2-Trifluoroacetic Acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide; |
| Synonyms: | J147 |
| 分子量: | 350.34 |
| 分子式: | C₁₈H₁₇F₃N₂O₂ |
| SMILES: | O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | J-147 是一种特别有效的，具有口服活性的神经保护剂，可增强认知能力。J-147 可透过血脑屏障 (BBB)。J-147 抑制单胺氧化酶 B (MAO B) 和多巴胺转运体 (dopamine transporter)，EC50分别为 1.88 μM 和 0.649 μM。J-147 有潜力用于阿尔茨海默氏症 (AD) 的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chen, J., et al.: J. Neurosci., 25, 2366 (2005), Maher, P., et al.: Brain Res., 1173, 117 (2007), Liu, Y., et al.: J. Neurochem., 105, 1336 (2008), Herrup, K., et al.: J. Neurosci., 30, 16755 (2010)
