Lazabemide
Cat. No.：YN380094
| 产品名称: | Lazabemide |
| CAS No.: | 103878-84-8 |
| Chemical Name: | N-(2-aminoethyl)-5-chloro-2-pyridinecarboxamide |
| Synonyms: | 拉扎贝胺; Ro 19-6327 |
| 分子量: | 199.64 |
| 分子式: | C₈H₁₀ClN₃O |
| SMILES: | ClC1=CC=C(C(NCCN)=O)N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lazabemide (Ro 19-6327) 是单胺氧化酶 B (MAO-B) 的选择性的可逆抑制剂 (IC50=0.03 μM)，但对 MAO-A (IC50>100 μM) 活性较低。高浓度 Lazabemide 具有抑制单胺摄取的作用，抑制去甲肾上腺素、血清素和多巴胺摄取的 IC50值分别为 86 μM、123 μM 和 >500 μM。Lazabemide 可用于帕金森和阿尔茨海默病的研究。 |
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Cesura, A.M., Gottowik, J., Lahm, H.W., et al.Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesisEur. J. Biochem.236(3),996-1002(1996)
Ozaita, A., Olmos, G., Boronat, M.A., et al.Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liverBr. J. Pharmacol.121(5),901-912(1997)
Henriot, S., Kuhn, C., Kettler, C., et al.Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: Preclinical and clinical findingsJ. Neural Transm. Suppl.41,321-325(1994)
Suzuki, T., Akaike, N., Ueno, K., et al.MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in micePharmacology50(6),357-362(1995)
