Rasagiline
Cat. No.：YN380104
| 产品名称: | Rasagiline |
| CAS No.: | 136236-51-6 |
| Chemical Name: | (1R)-2,3-dihydro-N-2-propyn-1-yl-1H-inden-1-amine |
| Synonyms: | 雷沙吉兰; AGN1135; TVP1012 |
| 分子量: | 171.24 |
| 分子式: | C₁₂H₁₃N |
| SMILES: | C#CCN[C@H]1C2=CC=CC=C2CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rasagiline(AGN1135;TVP1012)是MAO-B抑制剂，可作用于原发性帕金森病。 |
| IC50和靶点: | [{name:"rMAO-B:4.43 nM (IC50)"},{name: "rMAO-A:412 nM (IC50)"}] |
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Youdim, M.B.H., Gross, A., and Finberg, J.P.Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase BBrit. J. Pharmacol.132(2),500-506(2001)
Youdim, M.B.H., and Weinstock, M.Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]Cell. Mol. Neurobiol.21(6),555-573(2001)
Kang, S.S., Ahn, E.H., Zhang, Z., et al.α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's diseaseEMBO J.37(12),e98878(2018)
