Safinamide
Cat. No.：YN380147
| 产品名称: | Safinamide |
| CAS No.: | 133865-89-1 |
| Chemical Name: | |
| Synonyms: | 沙芬酰胺; FCE 26743; EMD 1195686 |
| 分子量: | 302.34 |
| 分子式: | C₁₇H₁₉FN₂O₂ |
| SMILES: | O=C([C@@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Safinamide 是一种有效的、选择性的、可逆的单胺氧化酶 B (MAO-B) 的抑制剂 (IC50=0.098 µM)，对 MAO-A (IC50=580 µM) 选择性较低。Safinamide 也阻断钠通道和调节谷氨酸 (Glu) 释放，在去极化时 (IC50= 8 µM) 比静息电位 (IC50=262 µM) 时，显示出更大的亲和力。Safinamide 具有神经保护作用，可用于帕金森病、缺血脑卒中等疾病的研究。 |
| IC50和靶点: | [{name:"MAO-B:98 nM (IC50)"},{name: "MAO-A:580 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
