Safinamide mesylate
Cat. No.：YN380148
| 产品名称: | Safinamide mesylate |
| CAS No.: | 202825-46-5 |
| Chemical Name: | 2S-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide, monomethanesulfonate |
| Synonyms: | FCE 26743 mesylate; EMD 1195686 mesylate |
| 分子量: | 398.45 |
| 分子式: | C₁₈H₂₃FN₂O₅S |
| SMILES: | C[C@H](NCC1=CC=C(OCC2=CC=CC(F)=C2)C=C1)C(N)=O.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Safinamide (FCE 26743; EMD 1195686) mesylate 是一种有效的、选择性的、可逆的单胺氧化酶 B (MAO-B) 的抑制剂 (IC50=0.098 µM)，对 MAO-A (IC50=580 µM) 选择性较低。Safinamide mesylate 也阻断钠通道和调节谷氨酸 (Glu) 释放，在去极化时 (IC50= 8 µM) 比静息电位 (IC50=262 µM) 时，显示出更大的亲和力。Safinamide mesylate 具有神经保护作用，可用于帕金森病 |
| IC50和靶点: | [{name:"MAO-B:98 nM (IC50)"},{name: "MAO-A:580 nM (IC50)"}] |
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Fariello, R.G., McArthur, R.A., Bonsignori, A., et al.Preclinical evaluation of PNU-151774E as a novel anticonvulsantJ. Pharmacol. Exp. Ther.285(2),397-403(1998)
